منابع مشابه
The Stemness Phenotype Model
The identification of a fraction of cancer stem cells (CSCs) associated with resistance to chemotherapy in most solid tumors leads to the dogma that eliminating this fraction will cure cancer. Experimental data has challenged this simplistic and optimistic model. Opposite to the classical cancer stem cell model, we introduced the stemness phenotype model (SPM), which proposed that all glioma ce...
متن کاملCoupling the modules of EMT and stemness: A tunable ‘stemness window’ model
Metastasis of carcinoma involves migration of tumor cells to distant organs and initiate secondary tumors. Migration requires a complete or partial Epithelial-to-Mesenchymal Transition (EMT), and tumor-initiation requires cells possessing stemness. Epithelial cells (E) undergoing a complete EMT to become mesenchymal (M) have been suggested to be more likely to possess stemness. However, recent ...
متن کاملthe use of appropriate madm model for ranking the vendors of mci equipments using fuzzy approach
abstract nowadays, the science of decision making has been paid to more attention due to the complexity of the problems of suppliers selection. as known, one of the efficient tools in economic and human resources development is the extension of communication networks in developing countries. so, the proper selection of suppliers of tc equipments is of concern very much. in this study, a ...
15 صفحه اولStemness in the Niche
Reprogramming committed differentiated cells into stable stem cells has been achieved in various settings in vitro. A new study by Tata et al. (2013) demonstrates that, when airway basal stem cells are in demand, spontaneous reprogramming occurs in vivo as committed secretory cells convert into stem cells to replenish the stem cell pool. The authors use lineage-tracing strategies to show that, ...
متن کاملDeconstructing stemness.
Stem cells are unique in their capacity to self-renew and generate differentiated progeny to maintain tissues throughout life. A common molecular program for stem cells has remained elusive. We discuss what the molecular logic of stemness may be. We suggest that it may not be coupled to distinct cellular properties such as self-renewal or multipotency, but rather to the stable suspension at a s...
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ژورنال
عنوان ژورنال: ISRN Oncology
سال: 2012
ISSN: 2090-567X
DOI: 10.5402/2012/392647